The ischemic preconditioning and postconditioning effect on the intestinal mucosa of rats undergoing mesenteric ischemia/reperfusion procedure

Acta Cirurgica Brasileira

Carlos Henrique Marques Dos Santos²  Otoni Moreira Gomes¹  José Carlos Dorsa Vieira Pontes²  Luciana Nakao Odashiro Miiji¹  Marco Aurélio Feltrin Bispo¹ 

[1] ,UFMS Surgery Department Campo Grande Mato Grosso do Sul ,Brazil

关键词: Ischemia;    Reperfusion;    Ischemic Preconditioning;    Rats;    Isquemia;    Reperfusão;    Precondicionamento Isquêmico;    Ratos;   

DOI  :  10.1590/S0102-86502008000100005

来源: SciELO

【 摘 要 】

PURPOSE: To evaluate the effect of the ischemic preconditioning and the ischemic postconditioning over the tissue injury in the intestinal mucosa of rats undergoing the procedure of mesenteric ischemia and reperfusion. METHODS: Thirty Wistar rats were studied, divided in three groups: group A, undergoing mesenteric ischemia (30 minutes) and reperfusion (60 minutes); group B, mesenteric ischemia and reperfusion preceded by ischemic preconditioning; group C, mesenteric ischemia and reperfusion and, before the beginning of reperfusion, the ischemic postconditioning was performed. At the end, a segment of the small intestine was dissected for histological analysis. The results were evaluated using the CHIU et al.6 classification followed by the statistic treatment. RESULTS: The mean values of the tissue injury levels were: group A, 3.5; group B, 1.2; and group C, 1. The difference between the result of group A with the results of groups B and C was considered statistically significant (p < 0,05). CONCLUSION: The ischemic preconditioning and postconditioning are able to minimize the tissue injury in the intestines of rats that underwent the procedure of mesenteric ischemia and reperfusion.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License