Myocardial protection by continuous, blood, antegrade-retrograde cardioplegia in rabbits

Acta Cirurgica Brasileira

Antônio Sérgio Martins²  Marcos Augusto De Moraes Silva²  Carlos Roberto Padovani¹  Beatriz Boljokian Matsubara¹  Domingo Marcolino Braile¹  Antonio José Maria Catâneo² 

[1] ,UNESP Surgery Department Botucatu,Brazil

关键词: Ventricular Function;    Ischemia;    Myocardium;    Animal;    Models;    Heart Arrest;    Induced;    Rabbits;    Função Ventricular;    Isquemia;    Miocárdio;    Modelos Animais;    Parada Cardíaca Induzida;    Coelhos;   

DOI  :  10.1590/S0102-86502007000100008

来源: SciELO

【 摘 要 】

PURPOSE: To study the effectiveness of the continuous, blood, antegrade-retrograde cardioplegia in an experimental model of isolated heart, evaluating ventricular function. METHODS: Rabbits were divided into four groups: Control-C(n=10); ischemic crystalloid cardioplegia-IC(n=10); ischemic blood cardioplegia-IB(n=10); ischemic non cardioplegia-INC(n=10). After the ischemic protocol period the ventricular function was analyzed by the intra-ventricular balloon technique. RESULTS: the intra-ventricular developed pressure (IVDP) was: C(92.90±6.86mmHg); IC(77.78±6.15mmHg); IB(93.64±5.09mmHg); INC(39.46 ±8.91mmHg) p<0.005. The first derivative of intra-ventricular pressure in its positive deflection was: C(1137.50± 92.23mmHg/sec); IC(1130.62 ±43.78mmHg/sec); IB(1187.58± 88.38mmHg/sec); INC(620.02± 43.80mmHg/se) p<0.005. The first derivate pressure in its negative deflection was: C(770.00± 73.41mmHg/sec); IC(610.03 ±47.43mmg/sec); IB(762.53 ±46.02mmHg/sec); INC(412.35 ±84.36mmHg/sec) p<0,005. The stress-strain angular logarithmic coefficient was: C(0.108± 0.02); IC(0.159± 0.038); IB(0.114 ±0.016); INC(0.175± 0.038) p<0.05. CONCLUSION: The ischemic group protected by blood cardioplegia showed better ventricular function than ischemic group protected by crystalloid cardioplegia and the non protected group.

【 授权许可】

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