Prophylaxis of deep-vein thrombosis after lower extremity amputation: Comparison of low molecular weight heparin with unfractionated heparin

Acta Cirurgica Brasileira

Sidney Lastória¹  Hamilton A. Rollo¹  Winston Bonetti Yoshida¹  Mariangela Giannini¹  Regina Moura¹  Francisco H. A. Maffei¹ 

[1] ,UNESP SMB Department of Surgery and OrthopedicsSão Paulo,Brazil

关键词: Amputation;    Venous Thrombosis;    Heparin;    Prevention & Control;    Amputação;    Trombose Venosa;    Heparina de Baixo Peso Molecular;    Prevenção & Controle;   

DOI  :  10.1590/S0102-86502006000300011

来源: SciELO

【 摘 要 】

PURPOSE: To compare the efficacy and safety of a low molecular weight heparin (enoxaparin) with unfractionated heparin (UH) in this prophylaxis. METHODS: Seventy five patients (59 men and 16 women), undergoing major lower extremity amputation (30 above-knee and 45 below-knee), were randomized to be treated with subcutaneous UH (5,000 IU t.i.d.) or enoxaparin (40mg/day) during hospitalization. Prophylaxis was started 12 hours before surgery or, in emergency cases, in the first postoperative day. RESULTS: The two groups were comparable with regard to baseline characteristics. Evaluation of DVT was performed by daily clinical examination and by duplex scanning before and 5 to 8 days after surgery. DVT was documented in the operated limb in 9.75% in patients treated with enoxaparin and in 11.76% in patients treated with UH (p=0.92) and there was one bilateral thrombosis in each group . Bleeding complications were not observed in both groups. CONCLUSION: Enoxaparin and UH were both efficient and safe for the prophylaxis of DVT in patients submitted to lower extremity amputation.

【 授权许可】

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