Effects of acetylsalicylic acid and acetic acid solutions in VX2 carcinoma cells: In vitro analysis

Acta Cirurgica Brasileira

Rogério Saad-hossne²  René Gamberini Prado²  William Saad Hossne¹ 

[1] ,Paulista State University Botucatu Medical School Department of Surgery and Orthopedics,Brazil

关键词: Carcinoma;    Aspirin;    Acetic Acid;    In vitro;    Carcinoma;    Aspirina;    Ácido Acético;    In vitro;   

DOI  :  10.1590/S0102-86502006000300006

来源: SciELO

【 摘 要 】

PURPOSE: To analyze, in vitro, the effects of acetylsalicylic acid (aspirin) and acetic acid solutions on VX2 carcinoma cells in suspension and to examine the correlation between these effects and neoplastic cell death. METHODS: The VX2 tumor cells (10(7) cells/ml) were incubated in solutions containing differing concentrations (2.5% and 5%) of either acetylsalicylic acid or acetic acid, or in saline solution (controls). Every five minutes, cell viability was tested (using the trypan blue test) and analyzed under light microscopy. RESULTS: Tumor cell viability (in %) decreased progressively and, by 30 minutes, neoplastic cell death had occurred in all solutions. CONCLUSION: Based on this experimental model and the methodology employed, we conclude that these solutions cause neoplastic cell death in vitro.

【 授权许可】

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