Experimental model of the morphological and morphometric aspects of tissue repair in skin wounds submitted to beta radiation emitted by Strontium -90 in rats

Acta Cirurgica Brasileira

Gerson Vilhena Pereira Filho²  José Mario Camelo-nunes¹  Fabrício Yui¹ 

[1] ,Federal University of São Paulo Paulista School of Medicine

关键词: Models;    Animal;    Wound healing;    Beta radiation;    Rats;    Histological study;    Modelos animais;    Reparação tecidual;    Radiação beta;    Ratos;    Estudo histológico;   

DOI  :  10.1590/S0102-86502004000700010

来源: SciELO

【 摘 要 】

The purperose of this work is tell the use of the experimental model to investigation of the effects of Beta radiation of estroncium-90 for repairing the tissue of wounds made in rats. 48 animals of the lineage EPM-1 Wistar were used, distributed in two groups that received radiation in alternate days (group A) and daily (group B). Each group was divided in four groups of six rats to be analysed in the 3rd, 7th, 14th and 21st day after operation. Two incisions were made in the back of the animal and sutured immediately afterwards; the upper part was irradiated and the lower part used as control. On the dates established the irradiated and control wounds were macroscopically examined and withdrawn for preparation of the histological comparative study in the optical microscope. Following, an morphometrical analysis was performed to count leucocyts, fiberblast and colagen fibers which were submitted to statistical study.

【 授权许可】

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