Ligation of the abdominal esophagus decreases scorpion toxin-induced gastric secretion in rats

Acta Cirurgica Brasileira

Claudia S. Vidal²  Marcus Vinicius Melo Andrade²  Gisele Viana¹  Alcino L. Silva¹  Tasso Moraes-santos¹  Heloísa M. S. Gonzaga¹  José Renan Cunha-melo¹ 

[1] ,Federal University of Minas Gerais Faculty of Medicine

关键词: Tityus serrulatus;    Scorpion venoms;    Gastric secretion;    Esophageal ligation;    Tityus serrulatus;    Veneno de escorpião;    Secreção gástrica;    Ligadura do esôfago;   

DOI  :  10.1590/S0102-86502004000300002

来源: SciELO

【 摘 要 】

PURPOSE: Scorpion toxin purified from Tityus serrulatus venom (Tx) induces an increase in volume, acidity and pepsin secretion in the gastric juice of rats. Ligation of oesophagus has been shown to reduce the acid gastric secretion in rats. The aim of this paper was to determine the influence of the esophageal ligation on gastric secretion induced by Tx in rats METHODS: Forty-four male albino rats were given water ad libitum, but no food for 20 to 24 hours, anesthetized with urethane and the trachea and jugular vein cannulated. Cervical or abdominal esophageal ligation or sham-operations were performed before and after the injection of 0.25 mg/kg of scorpion toxin (fraction T1) into the jugular vein. One hour later, the volume, acidity, pH and peptic activity of gastric juice were determined. RESULTS: The scorpion toxin induced an increase in gastric juice volume, acidity and pepsin output and a decrease in pH when injected into the vein of intact animals or in sham-operated animals. Cervical esophagus ligation did not interfere with the effects of toxin, however, ligation of the abdominal esophageal decreased the toxin effect on the rat stomach. CONCLUSION: Ligation of the abdominal esophagus decreases the gastric secretion induced by scorpion toxin.

【 授权许可】

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