VEGF immunoexpression in penile carcinoma

Acta Cirurgica Brasileira

Antonio Carlos Pereira Martins¹  Sérgio Britto¹  Clécio Takata¹  Haylton Jorge Suaid¹  Adauto José Cologna¹  Silvio Tucci Jr¹  Whemberton M. Araujo¹ 

[1] ,USP FMRP

关键词: Penile carcinoma;    squamous cell carcinoma of the penis;    CD34;   

DOI  :  10.1590/S0102-86502002000900011

来源: SciELO

【 摘 要 】

OBJECTIVE: To investigate the vessel endothelial growth factor (VEGF) as a risk factor in squamous cell carcinoma of the penis (SCCP). METHODS: Forty-seven patients with penile carcinoma were evaluated retrospectively. The mean age and standard deviation were 61.1±11.7 years. All of them were treated by penectomy and those with positive nodes underwent groin lymphadenectomy. Tumor grading was 35 G1 and 12 G2/3. Primary lesion stage was 24 pT1 and 23 pT2-4. Positive inguinal nodes were observed in 15 patients. Selected paraffin embedded sections were submitted to VEGF immunohistochemical analysis by the avidin-biotin-immunoperoxidase method with antigen retrieval. All slides were examined using an automatic analyzer system and the proportion of labeled cells in 10 high magnification power fields (400X) were recorded in a blind analysis. RESULTS: Median (%) labeling index was 2.3 in G1 versus 2.2 in G2/3 tumors (p=0.60), and 4.0 in pT1 versus 1.8 pT2-4 tumors (p=0.10). The respective data for pN0 patients was 2.8 and for pN+ was 2.1 (p=0.20). Survival curves showed no association with patients survival. CONCLUSION: In squamous cell carcinoma of the penis the VEGF immunoexpression has no association with tumor grade or stage, as well as with patient survival.

【 授权许可】

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