CD34 immunoexpression in penile carcinoma

Acta Cirurgica Brasileira

Antonio Carlos Pereira Martins²  Sérgio Britto²  Clécio Takata²  Silvio Tucci Jr.²  Tiago José Borelli-bovo¹  José Anastácio Dias Neto¹ 

[1] ,Universidade de São Paulo Faculdade de Medicina de Ribeirão Preto

关键词: Penile carcinoma;    squamous cell carcinoma of the penis;    CD34;   

DOI  :  10.1590/S0102-86502002000900003

来源: SciELO

【 摘 要 】

OBJECTIVE: To investigate microvessel density as a risk factor in squamous cell carcinoma of the penis. METHODS: Fifty patients with penile carcinoma were evaluated retrospectively. The mean age and standard deviation were 60.8±11.8 years. All of them were treated by penectomy and with positive nodes underwent groin lymphadenectomy. Tumor grading was 36 G1 and 24 G2/3. Primary lesion stage was 22 pT1 and 28 pT2-4. Positive inguinal nodes were observed in 18 patients. Selected paraffin embedded sections were submitted to CD34 immunohistochemical analysis by the avidin-biotin-immunoperoxidase method with antigen retrieval. All slides were examined using an automatic analyzer system and the number of micro-vessels in 10 high magnification power fields (400X) were counted in a blind analysis. RESULTS: Median number of microvessels was 631 in G1 versus 695 in G2/3 tumors (p=0.78), and 696 in pT1 versus 566 pT2-4 tumors (p=0.23). The respective data for pN0 patients was 525 and for pN+ was 696 (p=0.01), which is an unexpected result. CONCLUSION: CD34 immunoexpression or microvessel density determined by this method bear no association with tumor grade, stage or prognosis.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License