Gas tonometry for evaluation of gastrointestinal mucosal perfusion: experimental and clinical sepsis¹. part 2

Acta Cirurgica Brasileira

Eliezer Silva²  Luiz Francisco Poli De Figueiredo¹  Ruy Jorge Cruz Jr¹  Maurício Rocha E Silva¹ 

[1] ,Univ. Santo Amaro Internal Medicine

关键词: Septic shock;    Multiple organ failure;    Tonometry;    Sepsis;    Catecholamines;    Gut mucosa;    Choque séptico;    Falência de múltiplos órgãos;    Tonometria;    Sepse;    Catecolaminas;    Mucosa intestinal;   

DOI  :  10.1590/S0102-86502002000500003

来源: SciELO

【 摘 要 】

Substantial clinical and animal evidences indicate that the mesenteric circulatory bed, particularly the gut mucosa, is highly vulnerable to reductions in oxygen supply and prone to early injury in the course of hemodynamic changes induced by sepsis and septic shock. Gut hypoxia or ischemia is one possible contributing factor to gastrointestinal tract barrier dysfunction that may be associated with the development of systemic inflammatory response and multiple organ dysfunction syndrome, the principal cause of death after sepsis. Monitoring gut perfusion during experimental and clinical sepsis may provide valuable insights over new interventions and therapies highly needed to reduce multiple organ dysfunction and sepsis-related morbidity and mortality. We present our experience with gas tonometry as a monitor of the adequacy of gastrointestinal mucosal perfusion in experimental models sepsis and with the use of vasoactive agents for hemodynamic management in patients with septic shock.

【 授权许可】

CC BY   
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