Biocompatibility of Ricinus communis polymer with addition of calcium carbonate compared to titanium. Experimental study in guinea pigs

Revista Brasileira de Cirurgia Cardiovascular

Yorgos Luiz Santos De Salles Graça¹  Ana Cristina Opolski¹  Barbara Evelin Gonçalves Barboza¹  Bruna Olandoski Erbano¹  Caroline Cantalejo Mazzaro¹  Flávia Caroline Klostermann¹  Enéas Eduardo Sucharski¹  Luiz Fernando Kubrusly¹ 

关键词: Bioprosthesis materials;    Heart;    artificial Guinea pigs;    Implants;    Experimental;    Ricinus communis;    Boiocompatible;    Inflammation;    Implante de Prótese;    Coração Artificial;    Cobaias;    Implantes Experimentais;    Ricinus communis;    Biocompatível;    Inflamação;   

DOI  :  10.5935/1678-9741.20140030

来源: SciELO

【 摘 要 】

Objective: The aim of the present investigation was to determine whether the difference in inflammatory tissue reaction between the Riccinus communis (castor) polymer with calcium carbonate and the titanium implant is statistically significant. Methods: Thirty-two Cavia porcellus were allocated into four groups of eight animals each. We implanted the two types of materials in the retroperitoneal space of all the animals. They were euthanized at 7, 20, 30 and 40 days after surgery, and an histological study of the samples was conducted. Results: All implants showed characteristics of chronic inflammation regardless of the material and timepoint of evaluation. There was no statistically significant difference between Pm+CaCO3 and Ti with regard to the presence of granulation tissue, tissue congestion, histiocytes, lymphocytes, neutrophils, giant cells, and fibrosis (P> 0.05). Conclusion: The castor oil polymer plus calcium carbonate implant was not statistically different from the titanium implant regarding inflammatory tissue reaction.

【 授权许可】

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