Cystic medial necrosis: pathological findings and clinical implications

Revista Brasileira de Cirurgia Cardiovascular

Shi-min Yuan¹  Hua Jing¹ 

[1] ,Nanjing University Clinical School of Medicine Jinling Hospital

关键词: Aorta;    Cardiovascular Abnormalities;    Connective Tissue;    Pathology;    Clinical;    Aorta;    Anormalidades Cardiovasculares;    Tecido Conjuntivo;    Patologia Clínica;   

DOI  :  10.1590/S0102-76382011000100019

来源: SciELO

【 摘 要 】

Cystic medial necrosis (CMN) is a disorder of large arteries, in particular the aorta, characterized by an accumulation of basophilic ground substance in the media with cyst-like lesions. CMN is known to occur in certain connective tissue diseases such as Marfan syndrome, Ehlers-Danlos syndrome, and annuloaortic ectasia, which usually result from degenerative changes in the aortic wall. The relationships between CMN and congenital heart defects as well as other disorders have been evidenced. The mechanisms are still controversial, even though many molecular studies have been conducted. The aim of the present article is to provide a comprehensive overview of the CMN lesion in terms of pathologic features, clinical implications and etiologies based on molecular research results.

【 授权许可】

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