Nitrite exhaled breath condensate study in patients undergoing cardiopulmonary bypass cardiac surgery

Revista Brasileira de Cirurgia Cardiovascular

Viviane Dos Santos Augusto²  Graziela Saraiva Reis¹  Verena Kise Capellini¹  Andrea Carla Celotto¹  Alfredo José Rodrigues¹  Paulo Roberto Barbosa Evora¹ 

[1],USP FMRP Hospital das Clínicas de Ribeirão Preto

关键词: Nitrites;    Nitric Oxide;    Respiratory Function Tests;    Thoracic Surgery;    Cardiaca Surgical Procedures;    Nitritos;    Óxido Nítrico;    Testes de Função Respiratória;    Cirurgia Torácica;    Procedimentos Cirúrgicos Cardíacos;   

DOI  :  10.1590/S0102-76382011000100006

来源: SciELO

【 摘 要 】

BACKGROUND: There is a relative lack of studies on postoperative changes in nitrite (NO2 - ) concentrations, a marker of injury, following cardiac surgery. In this context, investigations on how exhaled NO concentrations vary in the postoperative period of cardiac surgery will certainly contribute to new clinical findings. OBJECTIVE: The objective of this study was to compare the EBC NO levels in both the pre and postoperative (24 hours) periods of cardiac surgery. METHODS: Twenty - eight individuals were divided into three groups: 1) control, 2) coronary artery bypass grafting, and 3) valve surgery. The nitrite (NO2 - ) levels were measured by chemiluminescence in blood samples and exhaled breath condensate (EBC). Data were analyzed by the Mann - Whitney and Wilcoxon tests. RESULTS: 1) Preoperatively, the EBC NO2 - levels from groups 2 and 3 patients were higher than control individuals; 2) The postoperative (24 hours) NO2 - levels in the EBC from group 3 patients were lower compared with preoperative values; 3) The NO2 - levels in the plasma from group 2 patients were lower in the preoperative compared with the postoperative (24h) values and; 4) Preoperatively, there was no difference between groups 2 and 3 in terms of plasma NO2 - concentrations. CONCLUSION: These data suggest that NO measurement in EBC is feasible in cardiac surgery patients.

【 授权许可】

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