The behavior of Troponin I and CKMB mass in children who underwent surgical correction of congenital heart malformations

Revista Brasileira de Cirurgia Cardiovascular

Pedro Rafael Salerno¹  Fabio Biscegli Jatene¹  Patrícia Elias Figueiredo¹  Ieda Jatene Bosisio¹  Marcelo Biscegli Jatene¹  Magaly Arraes Dos Santos¹  Luís Carlos Bento De Souza¹  Adib Domingos Jatene¹ 

关键词: Troponin I;    Creatine kinase;    Heart defects;    congenital;    Magnesium sulfate;    Cardioplegic solutions;    Troponina I;    Creatina quinase;    Cardiopatias congênitas;    Sulfato de magnésio;    Soluções cardioplégicas;   

DOI  :  10.1590/S0102-76382003000300008

来源: SciELO

【 摘 要 】

OBJECTIVE: To analyze the behavior of troponin (TROP I) and CKMB mass (CKMBm) in regards to the addition of magnesium in cardioplegic solutions; and also the influence of per-operative factors. METHOD: A total of 28 children with ages ranging from 3 to 108 months were studied. The mean weight was 11.8 kg. Eighteen were male. The patients were divided into two groups. Sixteen children in group I (GI) and 12 in group II (GII). The patients in GI received cold blood cardioplegic solution with magnesium (12 mEq/L) and potassium chloride (20 mEq/L) at 20 mL/kg. The patients in GII received the same solution without magnesium. Six blood samples were collected for serum analysis of the concentration of TROP I and CKMBm. The blood samples were collected before clamping the aorta and at 1, 6, 24, 48 and 72 hours after aorta clamping termination. RESULTS: There were no statistical differences in the TROP I and CKMBm levels between the two groups. Among the per-operative factors cyanosis influenced the TROP I and CKMBm levels. Additionally, the aorta clamping time influenced the TROP I levels. CONCLUSIONS: The addition of magnesium in the cardioplegic solution was not associated with different levels of TROP I and CKMBm. Cyanosis and aorta clamping time interfered with peak TROP I levels.

【 授权许可】

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