Revista Brasileira de Farmacognosia | |
Evaluation of acetylcholinesterase inhibitory activity of Brazilian red macroalgae organic extracts | |
Levi P. Machado1  Luciana R. Carvalho1  Maria Cláudia M. Young1  Elaine M. Cardoso-lopes1  Danilo C. Centeno1  Leonardo Zambotti-villela1  Pio Colepicolo1  Nair S. Yokoya1  | |
关键词: Acetylcholinesterase inhibition; Halogenated monoterpenes; Hypnea; Ochtodes; Pterocladiella; Rhodophyta; | |
DOI : 10.1016/j.bjp.2015.09.003 | |
来源: SciELO | |
【 摘 要 】
Abstract Alzheimer's disease affects nearly 36.5 million people worldwide, and acetylcholinesterase inhibition is currently considered the main therapeutic strategy against it. Seaweed biodiversity in Brazil represents one of the most important sources of biologically active compounds for applications in phytotherapy. Accordingly, this study aimed to carry out a quantitative and qualitative assessment of Hypnea musciformis (Wulfen) J.V. Lamouroux, Ochtodes secundiramea (Montagne) M.A. Howe, and Pterocladiella capillacea (S.G. Gmelin) Santelices & Hommersand (Rhodophyta) in order to determine the AChE effects from their extracts. As a matter of fact, the O. secundiramea extract showed 48% acetylcholinesterase inhibition at 400 μg/ml. The chemical composition of the bioactive fraction was determined by gas chromatography–mass spectrometry (GC–MS); this fraction is solely composed of halogenated monoterpenes, therefore allowing assignment of acetylcholinesterase inhibition activity to them.
【 授权许可】
CC BY-NC-ND
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