Revista Brasileira de Farmacognosia | |
Clinical safety evaluation of a tea containing Cissampelos sympodialis in healthy volunteers | |
Liane Franco Barros Mangueira1  Luciana Da Silva Nunes Ramalho1  Andressa Brito Lira1  Josué Do Amaral Ramalho1  Kardilandia Mendes Oliveira1  Aretuza Iolanda Pimentel De Almeida Torres1  Valério Marcelo Vasconcelos Do Nascimento1  Caliandra Maria Bezerra Luna Lima1  Cícero Flávio Soares Aragão1  Margareth De Fátima Formiga Melo Diniz1  | |
关键词: Clinical; Cissampelos sympodialis; Menispermaceae; Tea; | |
DOI : 10.1016/j.bjp.2015.06.009 | |
来源: SciELO | |
【 摘 要 】
ABSTRACTCissampelos sympodialis Eichler, Menispermaceae, is widely used by Indian tribes and folk medicine to treat various inflammatory disorders, including asthma. Clinical toxicological trials were made with the tea of C. sympodialis, a medicinal plant. The study took place at Lauro Wanderley Hospital/UFPB-PB, where seventeen healthy volunteers were chosen, among those six men and eleven women who orally ingested, during four weeks uninterruptedly, 150 ml of the tea, once a day. Before the first ingestion and after the last one, the participants were subjected to clinical and laboratorial tests for their overall conditions in order to analyze the toxicity of the plant. The results demonstrated that the volunteers neither experience clinical nor laboratorial alterations, as well as no significant adverse effects, apart from little change detected in their hematological tests. Nevertheless, none demonstrated any pathological conditions, just alterations of the normal human being physiology. Therefore, it is concluded that these data complement that obtained during pre-clinical studies and confirm a low toxicity of this plant.
【 授权许可】
CC BY-NC-ND
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