期刊论文详细信息
Revista Brasileira de Farmacognosia
Clinical safety evaluation of a tea containing Cissampelos sympodialis in healthy volunteers
Nascimento, Valério Marcelo Vasconcelos do1  Oliveira, Kardilandia Mendes1  Diniz, Margareth de Fátima Formiga Melo1  Mangueira, Liane Franco Barros1  Ramalho, Josué do Amaral1  Aragão, Cícero Flávio Soares1  Lira, Andressa Brito1  Universidade Federal de São Paulo, São Paulo, Brazil1  Torres, Aretuza Iolanda Pimentel de Almeida1  Lima, Caliandra Maria Bezerra Luna1  Ramalho, Luciana da Silva Nunes1  Universidade Federal do Rio Grande do Norte, Natal, Brazil1  Universidade Federal da Paraíba, João Pessoa, Brazil1 
关键词:  Clinical;    Cissampelos sympodialis;    Menispermaceae;    Tea;   
DOI  :  10.1016/j.bjp.2015.06.009
来源: Sociedade Brasileira de Farmacognosia
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【 摘 要 】

Cissampelos sympodialis Eichler, Menispermaceae, is widely used by Indian tribes and folk medicine to treat various inflammatory disorders, including asthma. Clinical toxicological trials were made with the tea of C. sympodialis, a medicinal plant. The study took place at Lauro Wanderley Hospital/UFPB-PB, where seventeen healthy volunteers were chosen, among those six men and eleven women who orally ingested, during four weeks uninterruptedly, 150 ml of the tea, once a day. Before the first ingestion and after the last one, the participants were subjected to clinical and laboratorial tests for their overall conditions in order to analyze the toxicity of the plant. The results demonstrated that the volunteers neither experience clinical nor laboratorial alterations, as well as no significant adverse effects, apart from little change detected in their hematological tests. Nevertheless, none demonstrated any pathological conditions, just alterations of the normal human being physiology. Therefore, it is concluded that these data complement that obtained during pre-clinical studies and confirm a low toxicity of this plant.

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