Clinical safety evaluation of a tea containing Cissampelos sympodialis in healthy volunteers

Revista Brasileira de Farmacognosia

Nascimento, Valério Marcelo Vasconcelos do¹  Oliveira, Kardilandia Mendes¹  Diniz, Margareth de Fátima Formiga Melo¹  Mangueira, Liane Franco Barros¹  Ramalho, Josué do Amaral¹  Aragão, Cícero Flávio Soares¹  Lira, Andressa Brito¹  Universidade Federal de São Paulo, São Paulo, Brazil¹  Torres, Aretuza Iolanda Pimentel de Almeida¹  Lima, Caliandra Maria Bezerra Luna¹  Ramalho, Luciana da Silva Nunes¹  Universidade Federal do Rio Grande do Norte, Natal, Brazil¹  Universidade Federal da Paraíba, João Pessoa, Brazil¹ 

关键词:  Clinical;    Cissampelos sympodialis;    Menispermaceae;    Tea;   

DOI  :  10.1016/j.bjp.2015.06.009

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Cissampelos sympodialis Eichler, Menispermaceae, is widely used by Indian tribes and folk medicine to treat various inflammatory disorders, including asthma. Clinical toxicological trials were made with the tea of C. sympodialis, a medicinal plant. The study took place at Lauro Wanderley Hospital/UFPB-PB, where seventeen healthy volunteers were chosen, among those six men and eleven women who orally ingested, during four weeks uninterruptedly, 150 ml of the tea, once a day. Before the first ingestion and after the last one, the participants were subjected to clinical and laboratorial tests for their overall conditions in order to analyze the toxicity of the plant. The results demonstrated that the volunteers neither experience clinical nor laboratorial alterations, as well as no significant adverse effects, apart from little change detected in their hematological tests. Nevertheless, none demonstrated any pathological conditions, just alterations of the normal human being physiology. Therefore, it is concluded that these data complement that obtained during pre-clinical studies and confirm a low toxicity of this plant.

【 授权许可】

Unknown