Cucumin S, a new phenylethyl chromone from Cucumis melo var. reticulatus seeds

Revista Brasileira de Farmacognosia

Sabrin R.m. Ibrahim¹  Gamal A. Mohamed¹ 

关键词: Cucumis melo;    Cucurbitaceae;    Chromone;    Flavonoid;    Antioxidant;   

DOI  :  10.1016/j.bjp.2015.06.006

来源: SciELO

【 摘 要 】

ABSTRACTA new phenylethyl chromenone, cucumin S [(R)-5,7-dihydroxy-2-[1-hydroxy-2-(4-hydroxy-3-methoxyphenyl)ethyl]chromone] (1), along with five known compounds: 5,7-dihydroxy-2-[2-(4-hydroxyphenyl)ethyl]chromone (2), 5,7-dihydroxy-2-[2-(3,4-dihydroxyphenyl)ethyl]chromone (3), luteolin (4), quercetin (5), and 7-glucosyloxy-5-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]chromone (6) were isolated from the EtOAc fraction of Cucumis melo var. reticulatus Ser., Cucurbitaceae, seeds. Their structures were determined by spectroscopic means (1D and 2D NMR), as well as HRESIMS, optical rotation measurement, and comparison with literature data. The isolated compounds 1–6 were assessed for their antioxidant activity using DPPH assay. Compounds 3, 4, and 5 showed potent activities compared to propyl gallate at concentration 100 µM.

【 授权许可】

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