Cucumin S, a new phenylethyl chromone from Cucumis melo var. reticulatus seeds

Revista Brasileira de Farmacognosia

Al-Azhar University, Assiut, Egypt¹  Assiut University, Assiut, Egypt¹  King Abdulaziz University, Jeddah, Saudi Arabia¹  Taibah University, Al Madinah Al Munawwarah, Saudi Arabia¹  Ibrahim, Sabrin R.M.¹  Mohamed, Gamal A.¹ 

关键词:   Cucumis melo;    Cucurbitaceae;    Chromone;    Flavonoid;    Antioxidant;   

DOI  :  10.1016/j.bjp.2015.06.006

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

A new phenylethyl chromenone, cucumin S [(R)-5,7-dihydroxy-2-[1-hydroxy-2-(4-hydroxy-3-methoxyphenyl)ethyl]chromone] (1), along with five known compounds: 5,7-dihydroxy-2-[2-(4-hydroxyphenyl)ethyl]chromone (2), 5,7-dihydroxy-2-[2-(3,4-dihydroxyphenyl)ethyl]chromone (3), luteolin (4), quercetin (5), and 7-glucosyloxy-5-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]chromone (6) were isolated from the EtOAc fraction of Cucumis melo var. reticulatus Ser., Cucurbitaceae, seeds. Their structures were determined by spectroscopic means (1D and 2D NMR), as well as HRESIMS, optical rotation measurement, and comparison with literature data. The isolated compounds 1–6 were assessed for their antioxidant activity using DPPH assay. Compounds 3, 4, and 5 showed potent activities compared to propyl gallate at concentration 100 µM.

【 授权许可】

Unknown