Antimicrobial activity of the myrsinoic acid A from Myrsine coriacea and the semi-synthetic derivatives

Revista Brasileira de Farmacognosia

Marcela Carmen De Melo Burger¹  Ana Paula Terezan¹  Gracielle Silva De Oliveira Cunha¹  Joao Batista Fernandes¹  Maria Fatima Das Graças Fernandes Da Silva¹  Paulo Cezar Vieira¹  Antonio Carlos Severo Menezes¹ 

关键词: Myrsine coriace;    Antimicrobial activity;    Primulaceae;    Myrsinoic acid A;   

DOI  :  10.1016/j.bjp.2015.07.023

来源: SciELO

【 摘 要 】

ABSTRACTThe antimicrobial activity of the myrsinoic acid A isolated from Myrsine coriacea (Sw.) R.Br. ex Roem. & Schult., Primulaceae, and a two semi-synthetics derivatives was tested against Bacillus subtilis, Escherichia coli, Salmonella enterica subsp. enterica serovar typhi, Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa, Micrococcus luteus, Candida albicans, Candida krusei and Candida tropicalis. The microdilution method was used for the determination of the minimum inhibitory concentration during evaluation of the antimicrobial activity. The myrsinoic acid A showed no activity against the selected microorganisms but the hydrogenated and acetylated derivatives were active against B. subtilis, E. coli, S. aureus and P. aeruginosa.

【 授权许可】

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