Antimicrobial activity of the myrsinoic acid A from Myrsine coriacea and the semi-synthetic derivatives

Revista Brasileira de Farmacognosia

Universidade Estadual de Goias, Anapolis, Brazil¹  Fernandes, Joao Batista¹  Burger, Marcela Carmen de Melo¹  Vieira, Paulo Cezar¹  Terezan, Ana Paula¹  Menezes, Antonio Carlos Severo¹  Silva, Maria Fatima das Graças Fernandes da¹  Cunha, Gracielle Silva de Oliveira¹  Universidade Federal de Sao Carlos, São Carlos, Brazil¹ 

关键词:   Myrsine coriace;    Antimicrobial activity;    Primulaceae;    Myrsinoic acid A;   

DOI  :  10.1016/j.bjp.2015.07.023

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The antimicrobial activity of the myrsinoic acid A isolated from Myrsine coriacea (Sw.) R.Br. ex Roem. & Schult., Primulaceae, and a two semi-synthetics derivatives was tested against Bacillus subtilis, Escherichia coli, Salmonella enterica subsp. enterica serovar typhi, Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa, Micrococcus luteus, Candida albicans, Candida krusei and Candida tropicalis. The microdilution method was used for the determination of the minimum inhibitory concentration during evaluation of the antimicrobial activity. The myrsinoic acid A showed no activity against the selected microorganisms but the hydrogenated and acetylated derivatives were active against B. subtilis, E. coli, S. aureus and P. aeruginosa.

【 授权许可】

Unknown