Effects of the oral treatment with Copaifera multijuga oil on reproductive performance of male Wistar rats

Revista Brasileira de Farmacognosia

Eduardo S. Gonçalves¹  Juliano R. Silva¹  Camila L. Gomes¹  Melissa B.l. Nery¹  Daniela M.a.f. Navarro¹  Geanne K.n. Santos¹  Jacinto C. Silva-neto¹  João H. Costa-silva¹  Alice V. Araújo¹  Almir G. Wanderley¹ 

关键词: Copaifera multijuga oil;    Copaiba oil;    Reproductive performance;    Reproductive toxicity;    Chronic treatment;    Behavioral parameters;   

DOI  :  10.1016/j.bjp.2014.07.014

来源: SciELO

【 摘 要 】

Copaiba oil, extracted from Copaifera multijuga Hayne, Fabaceae, is widely used for medicinal purposes, especially to treat inflammatory processes. However, there is no report regarding its effect on reproductive performance after used in repeated doses orally. The present study evaluated the effects of the oral administration of Copaiba oil (at doses of 200, 500 or 2500 mg/kg) or water (control) for eight weeks in male Wistar rats. Treated males mated untreated females, and parameters as fertility rates, absolute and relative mass of accessory sexual organs and histology and development of the offspring were evaluated. Chemical analysis revealed the presence of 22 components accounting for 99.11% of the Copaiba oil. The main compounds identified were sesquisterpenes. The reproductive toxicology results indicate that there was no difference between the treated groups compared with the control group in any of the parameters, suggesting that the oral treatment with C. multijuga oil for eight weeks does not affect reproductive performance of male Wistar rats.

【 授权许可】

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