Pharmacological evaluation of bee venom and melittin

Revista Brasileira de Farmacognosia

Camila G. Dantas¹  Tássia L.g.m. Nunes¹  Tâmara L.g.m. Nunes¹  Ailma O. Da Paixão¹  Francisco P. Reis¹  Waldecy De L. Júnior¹  Juliana C. Cardoso¹  Kátia P. Gramacho¹  Margarete Z. Gomes¹ 

关键词: Bee venom;    Dopamine;    Haloperidol;   

DOI  :  10.1590/0102-695X20142413365

来源: SciELO

【 摘 要 】

The objective of this study was to identify the pharmacological effects of bee venom and its major component, melittin, on the nervous system of mice. For the pharmacological analysis, mice were treated once with saline, 0.1 or 1.2 mg/kg of bee venom and 0.1 mg/kg of melittin, subcutaneously, 30 min before being submitted to behavioral tests: locomotor activity and grooming (open-field), catalepsy, anxiety (elevated plus-maze), depression (forced swimming test) and apomorphine-induced stereotypy. Haloperidol, imipramine and diazepam were administered alone (positive control) or as a pre-treatment (haloperidol).The bee venom reduced motor activity and promoted cataleptic effect, in a similar manner to haloperidol.These effects were decreased by the pretreatment with haloperidol. Both melittin and bee venom decreased the apomorphine-induced stereotypies. The data indicated the antipsychotic activity of bee venom and melittin in a murine model.

【 授权许可】

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