Investigation of protective effects of Erythrina velutina extract against MMS induced damages in the root meristem cells of Allium cepa

Revista Brasileira de Farmacognosia

Deborah S. B. S. Silva²  Benhur Barboza¹  Anuska C. F. S. Garcia²  Betejane De Oliveira²  Charles S. Estevam¹  Vitor A. Neto¹  Andre L. L. M. Santos¹  Antonio S. Dias¹  Ricardo Scher¹  Silmara M. Pantaleao¹ 

[1] ,Faculdade de Biociências Laboratório de Genética Molecular e Humana ,Brazil

关键词: Allium cepa;    antigenotoxicity;    chromosomal aberration;    Erythrina velutina;    Fabaceae;    root growth;   

DOI  :  10.1590/S0102-695X2013005000006

来源: SciELO

【 摘 要 】

Erythrina velutina Willd., Fabaceae, is a medicinal plant that can be found in the tropics and subtropics, including in the semi-arid northeastern Brazil. It is commonly used in folk medicine to treat anxiety, agitation and insomnia. E. velutina has been known to present analgesic, anti-inflammatory and antibacterial activities, however, it is unknown if this plant present a protective effect on DNA. We assessed the antigenotoxic effect of E. velutina against the genotoxic effects induced by MMS in the root meristem cells of Allium cepa. Three concentrations of the aqueous extract (100, 200 and 400 mg/L) of this medicinal plant were used in three different types of treatment (pre-, post- and simultaneous). The effects of the extracts on the root meristem cells of A. cepa were analyzed at both macroscopic and microscopic levels. Protective effects were observed at higher concentrations in pre-treatment and in simultaneous treatment. The results suggest that E. velutina may present antigenotoxic properties and demonstrate its chemopreventive potential.

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