Development of tablets containing semipurified extract of guaraná (Paullinia cupana)

Revista Brasileira de Farmacognosia

Traudi Klein¹  Renata Longhini¹  Marcos Luciano Bruschi¹  João Carlos Palazzo De Mello¹ 

[1] ,Universidade Estadual de Maringá Departamento de Farmácia ,Brazil

关键词: guaraná;    lactose;    microcrystalline cellulose;    microparticles;    Paullinia cupana;    tablets;   

DOI  :  10.1590/S0102-695X2012005000147

来源: SciELO

【 摘 要 】

This study evaluated the technological feasibility of producing a semipurified extract of guaraná (Paullinia cupana Kunth, Sapindaceae) in tablet form, using a direct-compression process. Maltodextrin and gum arabic were used to produce the extract microparticles, in order to protect the microparticles against such factors as temperature, oxidation, and humidity. Using pharmacopoeial methodologies, technological and physicochemistry tests (determination of residual moisture, of bulk and tapped density, Hausner ratio, compressibility and compactibility index, appearance, mean weight, hardness, friability, disintegration time, determination of EPA amount in tablets and in vitro release profile) were conducted. The formulation containing 200 mg of microparticles, 170 mg microcrystalline cellulose, and 10 mg lactose gave the best results in terms of hardness (116 N), friabilility (0.28%), mean weight (0.3821 g), and disintegration time (25 min) for a tablet designed for oral administration. The results met pharmacopoeial specifications, and the tablets are suitable for oral administration.

【 授权许可】

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