Anti-inflammatory and antinociceptive effects of the hydroethanolic extract of the flowers of Pyrostegia venusta in mice

Revista Brasileira de Farmacognosia

Clarice C. Veloso²  Layla D. M. Cabral²  Andressa D. Bitencourt²  Lidiane S. Franqui²  Flávia V. Santa-cecília¹  Danielle F. Dias¹  Roseli Soncini²  Fabiana C. Vilela²  Alexandre Giusti-paiva² 

[1] ,Universidade Federal de Alfenas Instituto de Ciências Biomédicas Laboratório de Ciências Fisiológicas,Brazil

关键词: anti-inflammatory;    antinociceptive;    Bignoniaceae;    Pyrostegia venusta;   

DOI  :  10.1590/S0102-695X2011005000209

来源: SciELO

【 摘 要 】

Pyrostegia venusta (Ker Gawl.) Miers, Bignoniaceae, is native to the Brazilian Cerrado and popularly known as "cipó-de-são-joão". In Brazilian folk medicine, the flowers of P. venusta are used as a general tonic and a treatment for diarrhea, vitiligo, cough, and common infections and inflammatory diseases of the respiratory system. Nevertheless, there are still no studies on its possible anti-inflammatory and antinociceptive effects. The P. venusta hydroethanolic extract (PvHE) was used to evaluate the anti-inflammatory and analgesic effects in carrageenan-induced paw edema, peritonitis induced by lipopolysaccharide, acetic acid-induced writhing, and formalin-induced paw-licking tests in Swiss male mice. PvHE at doses of 30-300 mg/kg p.o. demonstrated anti-inflammatory effect. PvHE reduced paw edema induced by carrageenan and inhibited leukocyte recruitment into the peritoneal cavity. The extracts showed antinociceptive activity in acetic acid-induced writhing and formalin tests. Our results showed that the PvHE demonstrated anti-inflammatory and antinociceptive action in mice. All the anti-inflammatory actions obtained are also suggested to due the presence of acacetin-7-O-β-glucopyranoside.

【 授权许可】

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