Mechanism involved in the anti-inflammatory effect of Spiranthera odoratissima (Manacá)

Revista Brasileira de Farmacognosia

Daniela B. M. Barbosa²  Marcus V. M. Nascimento²  Roberta C. Lino²  Marta R. Magalhães¹  Iziara F. Florentino²  Tereza C. D. Honório²  Pablinny M. Galdino²  Maria Teresa F. Bara¹  José R. De Paula¹  Elson A. Costa² 

[1] ,Universidade Federal de Goiás Instituto de Ciências Biológicas ,Brazil

关键词: anti-inflammatory;    antinociceptive;    medicinal plant;    phospholipase A2;    Spiranthera odoratissima;   

DOI  :  10.1590/S0102-695X2011005000154

来源: SciELO

【 摘 要 】

Acetic acid-induced writhing, hot-plate, carrageenan-induced pleurisy, formalin-induced pain, croton oil-induced ear edema, vascular permeability tests and phospholipase A2 activity assay were used to study the analgesic and/or anti-inflammatory activity of the hydromethanolic fraction of ethanolic extract from Spiranthera odoratissima A. St.-Hil., Rutaceae, leaves (HMF) and its subfraction (sub-Fr10-28). HMF and sub-Fr10-28 reduced the leukocyte migration on the carrageenan-induced pleurisy test; sub-Fr10-28 reduced the pain reaction time in the second phase of formalin-induced pain, as well as the ear edema and vascular permeability. Both HMF and sub-Fr10-28 inhibited the phospholipase A2 activity. These results suggest that the analgesic effect of this plant could be, in part, due to an anti-inflammatory action produced by the inhibition of phospholipase A2 activity.

【 授权许可】

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