Mechanism involved in the anti-inflammatory effect of Spiranthera odoratissima (Manacá)

Revista Brasileira de Farmacognosia

Lino, Roberta C.¹  Florentino, Iziara F.¹  Galdino, Pablinny M.¹  Magalhães, Marta R.¹  Barbosa, Daniela B. M.¹  Paula, José R. de¹  Pontifícia Universidade Católica de Goiás, Brazil¹  Honório, Tereza C. D.¹  Universidade Federal de Goiás, Brazil¹  Nascimento, Marcus V. M.¹  Bara, Maria Teresa F.¹  Costa, Elson A.¹ 

关键词: anti-inflammatory;    antinociceptive;    medicinal plant;    phospholipase A2;    Spiranthera odoratissima;   

DOI  :  10.1590/S0102-695X2011005000154

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Acetic acid-induced writhing, hot-plate, carrageenan-induced pleurisy, formalin-induced pain, croton oil-induced ear edema, vascular permeability tests and phospholipase A2 activity assay were used to study the analgesic and/or anti-inflammatory activity of the hydromethanolic fraction of ethanolic extract from Spiranthera odoratissima A. St.-Hil., Rutaceae, leaves (HMF) and its subfraction (sub-Fr10-28). HMF and sub-Fr10-28 reduced the leukocyte migration on the carrageenan-induced pleurisy test; sub-Fr10-28 reduced the pain reaction time in the second phase of formalin-induced pain, as well as the ear edema and vascular permeability. Both HMF and sub-Fr10-28 inhibited the phospholipase A2 activity. These results suggest that the analgesic effect of this plant could be, in part, due to an anti-inflammatory action produced by the inhibition of phospholipase A2 activity.

【 授权许可】

Unknown