Sulfated fucans extracted from algae Padina gymnospora have anti-inflammatory effect

Revista Brasileira de Farmacognosia

Cybelle Teixeira Marques²  Tarciana C. G. De Azevedo²  Marília S. Nascimento²  Valquíria P. Medeiros²  Luciana G. Alves²  Norma M. B. Benevides¹  Hugo A. O. Rocha²  Edda Lisboa Leite² 

[1] ,Universidade Federal do Rio Grande do Norte Centro de Biociências Departamento de Bioquímica,Brazil

关键词: algae;    assessment anti-inflammatory;    fucans;    nitric oxide;    Padina gymnospora;    sulfated polysaccharides;   

DOI  :  10.1590/S0102-695X2011005000206

来源: SciELO

【 摘 要 】

Sulfated polysaccharides were extracted with acetone from brown algae Padina gymnospora. The fraction precipitated with 1.5 volumes of acetone (F1.5) purified in Sephadex G-75 was characterized by infrared and nuclear magnetic resonance of 13C and ¹H, through which the presence of sulfate groups on the C4 of α-L-fucose could be observed. This polysaccharide showed that an MW of 25,000 Da was effective in reducing leukocyte influx into the peritoneal cavity in mice at 10 mg/kg and 25 mg/kg body weight, causing a decrease of 60 and 39%, respectively. In the present study, it was observed that this fucan has anti-inflammatory properties but no cytotoxic action, indicating its potential use in the pharmaceutical industry.

【 授权许可】

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