Sulfated fucans extracted from algae Padina gymnospora have anti-inflammatory effect

Revista Brasileira de Farmacognosia

Nascimento, Marília S.¹  Azevedo, Tarciana C. G. de¹  Benevides, Norma M. B.¹  Leite, Edda Lisboa¹  Universidade Federal do Ceará, Brazil¹  Rocha, Hugo A. O.¹  Medeiros, Valquíria P.¹  Universidade Federal do Rio Grande do Norte, Brazil¹  Marques, Cybelle Teixeira¹  Alves, Luciana G.¹ 

关键词: algae assessment anti-inflammatory fucans nitric oxide Padina gymnospora sulfated polysaccharides;   

DOI  :  10.1590/S0102-695X2011005000206

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Sulfated polysaccharides were extracted with acetone from brown algae Padina gymnospora. The fraction precipitated with 1.5 volumes of acetone (F1.5) purified in Sephadex G-75 was characterized by infrared and nuclear magnetic resonance of 13C and 1H, through which the presence of sulfate groups on the C4 of α-L-fucose could be observed. This polysaccharide showed that an MW of 25,000 Da was effective in reducing leukocyte influx into the peritoneal cavity in mice at 10 mg/kg and 25 mg/kg body weight, causing a decrease of 60 and 39%, respectively. In the present study, it was observed that this fucan has anti-inflammatory properties but no cytotoxic action, indicating its potential use in the pharmaceutical industry.

【 授权许可】

Unknown