Anti-inflammatory activities of the hydroalcoholic extracts from Erythrina velutina and E. mulungu in mice

Revista Brasileira de Farmacognosia

Silvânia M. M. Vasconcelos²  Gabriel T. M. Sales¹  Natália Lima²  Rodrigo De Freitas G. Lobato²  Danielle Silveira Macêdo²  José Maria Barbosa-filho¹  Luzia Kalyne A. M. Leal¹  Marta M. F. Fonteles²  Francisca Cléa F. Sousa²  Jeania Lima Oliveira²  Glauce S. B. Viana² 

[1] ,Universidade Federal do Ceará Faculdade de Medicina Departamento de Fisiologia e Farmacologia,Brazil

关键词: anti-inflammatory activity;    carrageenan;    dextran;    Erythrina velutina;    Erythrina mulungu;   

DOI  :  10.1590/S0102-695X2011005000134

来源: SciELO

【 摘 要 】

This work studied the anti-inflammatory activities of the hydroalcoholic extracts (HAEs) from Erythrina velutina Willd. (Ev) and E. mulungu Mart. ex Benth. (Em) in the carrageenan- and dextran-induced mice hind paw edema models. These medicinal plants belonging to the Fabaceae family are used in some Brazilian communities to treat pain, inflammation, insomnia and disorders of the central nervous system. In the present work, the extracts were administered orally in male mice at the doses of 200 or 400 mg/kg. In the carrageenan-induced test, only Em showed anti-inflammatory activity, decreasing the paw edema, at the doses of 200 and 400 mg/kg. No effect was observed with Ev in this model. On the other hand, in the dextran model, Ev demonstrated anti-inflammatory effect, showing decrease of the paw edema at the 1, 2, 3, 4 and 24th h. Em (200 or 400 mg/kg) presented anti-inflammatory effect at the 2, 3 and 4th h after administration of dextran, as compared to control. In conclusion, the work showed that Ev and Em present anti-edematous actions, which possibly occurs by distinct mechanisms. While Ev seems to interfere especially in inflammatory processes in which mast cells have an important role, Em exerts greater activity in the inflammatory process that depends mainly on polymorphonuclear leucocytes. However, further studies are needed to determine the exact mechanism of action of the species investigated.

【 授权许可】

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