Anti-inflammatory properties of Albuca setosa and its possible mechanism of action

Dynamic Chiropractic

E. J. Ndebia¹  E. Umapathy² 

[1] Department of Physiology, Walter Sisulu University, Mthatha, South Africa.;Department of Zoology, Walter Sisulu University, Mthatha, South Africa.

关键词: Albuca setosa;    inflammation;    carrageenan;    dextran;    histamine;    serotonin.;   

DOI  :  

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Albuca setosais used for the treatment of wounds, articulation problems and rheumatoid arthritis. In this study we characterized the anti-inflammatory response ofA. setosaon inflammation induced by carrageenan, dextran, histamine, serotonin, arachidonic acid and xylene.The extract was administered orally at a dose of 150 and 300 mg/kg.The extract ofA. setosaat bothdosessignificantly inhibited (P< 0.01) the formation of the carrageenan-induced rat paw edema in the first, second and the third hour of inflammation (peak of inflammation) by 52, 55, 43% and 68, 84, 85% for 150 and 300 mg/kg, respectively. Concerning inflammation induced by dextran and inflammatory mediators such as histamine, serotonin and arachidonic acid, the effect ofA. setosawas significant (P<0.01) mostly during the first and the second hours of inflammation by a maximum of inhibition of 61, 83, 50 and 47%, respectively.Results also showed thatwater leaf extract ofA. setosasignificantly inhibited (P< 0.05) topical edema in the mouse ear induced by xylene for 150 mg/kg by 44% but was not dose dependent.The results obtained suggest that the water leaf extract ofA. setosais endowed with effective anti-inflammatory activity mediated via either inhibition of phospholipase A2 (PLA2) activity or cyclooxygenase cascade and by blocking the release of vasoactive substances like histamine, serotonin and kinins.

【 授权许可】

Unknown