Antimicrobial activity, cytotoxicity and intracellular growth inhibition of Portuguese Thymus essential oils

Revista Brasileira de Farmacognosia

Susana A. Dandlen²  A. Sofia Lima¹  Marta D. Mendes¹  M. Graça Miguel¹  M. Leonor Faleiro¹  M. João Sousa¹  Luís G. Pedro¹  José G. Barroso¹  A. Cristina Figueiredo¹ 

[1] ,Universidade do Algarve Faculdade de Ciências e Tecnologia ,Portugal

关键词: anti-Helicobacter;    antimicrobial activity;    carvacrol;    cytotoxicity;    essential oil;    ThymeISSN 0102-695X;   

DOI  :  10.1590/S0102-695X2011005000155

来源: SciELO

【 摘 要 】

Thyme essential oils are well recognized by their excellent biological activities and the antimicrobial activity of Portuguese thyme essential oils has been investigated with promising results, particularly against food borne pathogens. In this study the potential antimicrobial activity of the essential oils of five species of Thymus (Lamiaceae), namely Th. caespititius Brot., Th. camphoratus Hoffmanns. & Link, Th. capitellatus Hoffmanns. & Link., Th. carnosus Boiss. and Th. zygis L. was evaluated against Candida albicans, Haemophilus influenza, Helicobacter pylori, Listeria monocytogenes, Salmonella enterica and Streptococcus pneumoniae. H. pylori strains were the most susceptible bacteria, particularly to the essential oils of Th. caespititius (Planalto Central), Th. zygis (Rebordãos) and Th. caespititius (Pico) which minimum inhibitory concentration (MIC) values ranged from 0.05 to 0.08 mg.mL-1. Th. caespititius essential oil from Planalto Central or its main component, carvacrol significantly (p<0.05) inhibited the intracellular growth of H. pylori, and showed no citotoxicity to the gastric cell line. Our results suggest the potential of this essential oil and its main component as a promising tool as anti-Helicobacter agent potentiating the eradication of this important gastroduodenal pathogen.

【 授权许可】

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