Bioactivity of the compounds isolated from Blepharocalyx salicifolius

Revista Brasileira de Farmacognosia

Ezequias P. Siqueira²  Djalma M. Oliveira¹  Susana Johann¹  Patrícia S. Cisalpino¹  Betania B. Cota²  Ana Rabello²  Tânia M. A. Alves²  Carlos L. Zani² 

[1] ,Centro de Pesquisa René Rachou,Brazil

关键词: biological assays;    Blepharocalyx salicifolius;    chalcone;    flavonoid;    Myrtaceae;    triterpene;   

DOI  :  10.1590/S0102-695X2011005000111

来源: SciELO

【 摘 要 】

Blepharocalyx salicifolius (Kunth) O. Berg, Myrtaceae, is an endemic species that occurs at Southern America. This species was studied to intend to isolation of the active compounds that could be used in vitro model against leishmaniosis, tumoral cell and paracoccidioidomycosis. After Gel Permeation Chromatography, the ethanolic extract from leaves yielded sixteen fractions. Five compounds were isolated and assayed, showing activity against tumoral cells, from 3.33 to 12.83 µg.mL-1; Leishmania (Leishmania) amazonensis from 2.19 to 20.80 µg.mL-1 and Paracoccidioides brasiliensis from 3.10 to 12.5 µg.mL-1.

【 授权许可】

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