Antiproliferative activity, isolation and identification of active compound from Gaylussacia brasiliensis

Revista Brasileira de Farmacognosia

Rodney Alexandre Ferreira Rodrigues²  João Ernesto De Carvalho²  Ilza Maria De Oliveira Sousa²  Marcia Aparecida Antônio¹  Paulo Eduardo Pizão¹  Luciana Konecny Kohn¹  Maria Do Carmo Estanislau Do Amaral¹  Volker Bittrich¹  Mary Ann Foglio² 

[1] ,Universidade de Campinas Centro Pluridiscip linar de Pesquisas Químicas, Biológicas e Agrícolas ,Brazil

关键词: antiproliferative;    Gaylussacia brasiliensis;    medicinal plants;   

DOI  :  10.1590/S0102-695X2011005000116

来源: SciELO

【 摘 要 】

Gaylussacia brasiliensis (Spreng.) Meissn., Ericaceae, is used in folk medicine for treatment of several inflammatory processes and as healing agent. The scope of this work was to evaluate the in vitro antiproliferative activity of crude dichloromethane extract (CHD) and to identify the compound(s) responsible for this activity. CHD was evaluated and showed a concentration dependent inhibition on all cells lines. Therefore CHD was submitted to several classical columns chromatography providing the most active fraction (FC), inhibiting all cells line at 25 µg/mL. FC was further fractionated affording isolated compound 2β, 3β-dihydroxy-urs-12-ene-28-oic acid , identified on basis of 2D-NMR experiments and showed concentration-dependent activity and selectivity for kidney and breast cell lines.

【 授权许可】

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