Antiproliferative activity, isolation and identification of active compound from Gaylussacia brasiliensis

Revista Brasileira de Farmacognosia

Amaral, Maria do Carmo Estanislau do¹  Foglio, Mary Ann¹  Antônio, Marcia Aparecida¹  Bittrich, Volker¹  Kohn, Luciana Konecny¹  Carvalho, João Ernesto de¹  Pizão, Paulo Eduardo¹  Universidade de Campinas, Brazil¹  Rodrigues, Rodney Alexandre Ferreira¹  Sousa, Ilza Maria de Oliveira¹ 

关键词: antiproliferative;    Gaylussacia brasiliensis;    medicinal plants;   

DOI  :  10.1590/S0102-695X2011005000116

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Gaylussacia brasiliensis (Spreng.) Meissn., Ericaceae, is used in folk medicine for treatment of several inflammatory processes and as healing agent. The scope of this work was to evaluate the in vitro antiproliferative activity of crude dichloromethane extract (CHD) and to identify the compound(s) responsible for this activity. CHD was evaluated and showed a concentration dependent inhibition on all cells lines. Therefore CHD was submitted to several classical columns chromatography providing the most active fraction (FC), inhibiting all cells line at 25 µg/mL. FC was further fractionated affording isolated compound 2β, 3β-dihydroxy-urs-12-ene-28-oic acid , identified on basis of 2D-NMR experiments and showed concentration-dependent activity and selectivity for kidney and breast cell lines.

【 授权许可】

Unknown