Chemical composition and effect of an essential oil of Salix aegyptiaca L., Salicaceae, (musk willow) in hypercholesterolemic rabbit model

Revista Brasileira de Farmacognosia

Isaac Karimi²  Hossein Hayatgheybi¹  Tayebeh Shamspur¹  Adem Kamalak¹  Mehrdad Pooyanmehr²  Yaser Marandi¹ 

[1] ,Razi University School of Veterinary Medicine Department of Biochemistry, Physiology and Pharmacology Kermanshah ,Iran

关键词: Salix aegyptiaca;    hypercholesterolemia;    essential oil;    1;    4-dimethoxybenzene;   

DOI  :  10.1590/S0102-695X2011005000030

来源: SciELO

【 摘 要 】

The essential oils (EO) of Salix aegyptiaca L., Salicaceae (SA), leaves were extracted using the hydrodistillation method and their chemical composition was further determined by GC-MS. 1,4-Dimethoxybenzene was the main isolated compound. Other major isolated constitutes were phenylethyl alcohol, carvone, citronellol, methyleugenol, eugenol, n-tetradecane and 4'-methoxyacetophenone. Twenty rabbits were equally divided into four groups: Normal control (NC) which fed a standard diet and three cholesterol-fed groups: HC, HC+1.0% SA and HC+3.0% SA groups which received 0.0%, 1.0% and 3.0% EO, respectively for four weeks. The serum lipid and lipoprotein profiles and atherogenic index (AI) were measured weekly. The high cholesterol diet significantly raised the TC, LDL-C, VLDL-C, HDL-C, TG and AI level compared with NC group. HC+1.0% SA and HC+3.0% SA groups showed similar results compared with HC group. It can be concluded that the EO of SA leaves could not prevent dyslipidemia that occurred in rabbits following inclusion of cholesterol in diet in both dose-and time-dependent manners.

【 授权许可】

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