Chemical composition and effect of an essential oil of Salix aegyptiaca L., Salicaceae, (musk willow) in hypercholesterolemic rabbit model

Revista Brasileira de Farmacognosia

Hayatgheybi, Hossein¹  Razi University, Iran¹  Marandi, Yaser¹  Kamalak, Adem¹  Karimi, Isaac¹  Islamic Azad University, Urmia branch, Iran¹  Urmia University, Iran¹  Shahid Bahonar University of Kerman, Iran¹  shamspur, Tayebeh¹  Kahramanmaras Sutcu Imam University, Turkey¹  Pooyanmehr, Mehrdad¹ 

关键词: Salix aegyptiaca;    hypercholesterolemia;    essential oil;    1;    4-dimethoxybenzene.;   

DOI  :  10.1590/S0102-695X2011005000030

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The essential oils (EO) of Salix aegyptiaca L., Salicaceae (SA), leaves were extracted using the hydrodistillation method and their chemical composition was further determined by GC-MS. 1,4-Dimethoxybenzene was the main isolated compound. Other major isolated constitutes were phenylethyl alcohol, carvone, citronellol, methyleugenol, eugenol, n-tetradecane and 4'-methoxyacetophenone. Twenty rabbits were equally divided into four groups: Normal control (NC) which fed a standard diet and three cholesterol-fed groups: HC, HC+1.0% SA and HC+3.0% SA groups which received 0.0%, 1.0% and 3.0% EO, respectively for four weeks. The serum lipid and lipoprotein profiles and atherogenic index (AI) were measured weekly. The high cholesterol diet significantly raised the TC, LDL-C, VLDL-C, HDL-C, TG and AI level compared with NC group. HC+1.0% SA and HC+3.0% SA groups showed similar results compared with HC group. It can be concluded that the EO of SA leaves could not prevent dyslipidemia that occurred in rabbits following inclusion of cholesterol in diet in both dose-and time-dependent manners.

【 授权许可】

Unknown