Anti-snake venom effect of secodolastane diterpenes isolated from Brazilian marine brown alga Canistrocarpus cervicornis against Lachesis muta venom

Revista Brasileira de Farmacognosia

Thaisa Francielle S. Domingos²  Magui Aparecida Vallim²  Carla Carvalho¹  Eladio Flores Sanchez¹  Valéria Laneuville Teixeira²  André Lopes Fuly¹ 

[1] ,Universidade Federal Fluminense Instituto de Biologia Niterói RJ ,Brazil

关键词: Canistrocarpus cervicornis;    seaweed;    diterpenes;    Lachesis muta;    snake venom;    antiophidian;   

DOI  :  10.1590/S0102-695X2011005000048

来源: SciELO

【 摘 要 】

The effect of a Brazilian algae extract and also a mixture of two secodolastane diterpenes (linearol/isolinearol) that were isolated from the marine brown alga Canistrocarpus cervicornis were evaluated against biological activities of Lachesis muta snake venom. In vitro assays showed that the crude extract and the diterpenes were able to inhibit the clotting and proteolytic activity induced by L. muta crude venom, but not the hemolytic activity. However, only the diterpenes inhibited the hemolysis caused by a purified phospholipase A2 previously isolated from L. muta venom, denoted LM-PLA2-I. Interestingly, the crude algal extract and the diterpenes were able to protect mice from hemorrhage induced by L. muta venom. Thus, we may conclude that marine algae are rich and powerful sources of molecules that may be used against L. muta accidents in order to improve treatment of envenomation by this snake.

【 授权许可】

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