Anti-snake venom effect of secodolastane diterpenes isolated from Brazilian marine brown alga Canistrocarpus cervicornis against Lachesis muta venom

Revista Brasileira de Farmacognosia

Sanchez, Eladio Flores¹  Teixeira, Valéria Laneuville¹  Fundação Ezequiel Dias, Belo Horizonte, Brazil¹  Universidade Federal Fluminense, Niterói, Brazil¹  Domingos, Thaisa Francielle S.¹  Carvalho, Carla¹  Fuly, André Lopes¹  Vallim, Magui Aparecida¹ 

关键词: Canistrocarpus cervicornis;    seaweed;    diterpenes;    Lachesis muta;    snake venom;    antiophidian;   

DOI  :  10.1590/S0102-695X2011005000048

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The effect of a Brazilian algae extract and also a mixture of two secodolastane diterpenes (linearol/isolinearol) that were isolated from the marine brown alga Canistrocarpus cervicornis were evaluated against biological activities of Lachesis muta snake venom. In vitro assays showed that the crude extract and the diterpenes were able to inhibit the clotting and proteolytic activity induced by L. muta crude venom, but not the hemolytic activity. However, only the diterpenes inhibited the hemolysis caused by a purified phospholipase A2 previously isolated from L. muta venom, denoted LM-PLA2-I. Interestingly, the crude algal extract and the diterpenes were able to protect mice from hemorrhage induced by L. muta venom. Thus, we may conclude that marine algae are rich and powerful sources of molecules that may be used against L. muta accidents in order to improve treatment of envenomation by this snake.

【 授权许可】

Unknown