Biological potential of Stillingia oppositifolia

Revista Brasileira de Farmacognosia

Betania Barros Cota²  Susana Johann²  Djalma M. Oliveira¹  Ezequias P. Siqueira²  Elaine M. Souza-fagundes¹  Patrícia S. Cisalpino¹  Tânia M. A. Alves²  Carlos Leomar Zani² 

[1] ,Fiocruz Centro de Pesquisas René Rachou Laboratório de Química de Produtos NaturaisBelo Horizonte MG ,Brazil

关键词: antifungal;    cytotoxic;    Euphorbiaceae;    Stillingia oppositifolia;    terpenoids;   

DOI  :  10.1590/S0102-695X2011005000016

来源: SciELO

【 摘 要 】

Organic extracts from leaves and stems of Stillingia oppositifolia Baill. ex Müll. Arg., Euphorbiaceae, were screened for antifungal and cytotoxic properties. The extracts presented Minimum Inhibitory Concentration values around 250 µg.mL-1 against Candida krusei and Candida tropicalis, and around 63 µg.mL-1 for Paracoccidioides brasiliensis. They were tested on three human cell lines (UACC-62, MCF-7, and TK-10), disclosing GI50 values, (concentration able to inhibit 50% of the cell growth) ranging from 50 to 100 µg.mL-1. Organic extract from stems furnished hexanic, dichloromethanic and aqueous phases after partition. Chromatographic fractionation of the hexanic soluble phase of the stems yielded aleuritolic acid 3-acetate, β-sitosterol, 3-epi-β-amyrin, β-amyrone and palmitic acid. These compounds showed antifungal and cytotoxic activities in the same range as the organic crude extract and low toxic effect against mononuclear cells obtained from human peripheral blood. This is the first report on chemical and biological potential of S. oppositifolia.

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