Antimicrobial activity of Pterogyne nitens Tul., Fabaceae, against opportunistic fungi

Revista Brasileira de Farmacognosia

Luis Octávio Regasini²  Marcos Pivatto¹  Liliana Scorzoni¹  Tatiane Benaducci¹  Ana Marisa Fusco-almeida¹  Maria José Soares Mendes Giannini¹  Eliezer Jesus Barreiro¹  Dulce Helena Siqueira Siva²  Vanderlan Da Silva Bolzani² 

[1] ,Universidade Estadual Paulista Júlio de Mesquita Filho Instituto de Química Departamento de Química OrgânicaAraraquara SP ,Brazil

关键词: Pterogyne nitens;    guanidine alkaloids;    antifungal;    opportunistic fungi;    Candida spp.;    Cryptococcus neoformans;    Pterogyne nitens;    alcaloides guanidínicos;    antifúngico;    fungos oportunistas;    Candida spp;    Cryptococcus neoformans;   

DOI  :  10.1590/S0102-695X2010005000017

来源: SciELO

【 摘 要 】

As part of our ongoing research on antifungal agents from Brazilian flora, eight extracts and twelve fractions from Pterogyne nitens Tul., Fabaceae, were screened for antimicrobial activity against four opportunistic fungi species (Candida albicans, Candida krusei, Candida parapsilosis and Cryptococcus neoformans) using a broth microdilution method. The present investigation reveals that P. nitens extracts and fractions were more effective against C. krusei and C. parapsilosis than against C. neoformans. The growth of C. albicans was moderately affected by all tested extracts and fractions. The strongest effects were observed for n-butanol fractions from branches (MIC = 15.6 μg/mL) and roots (MIC = 31.2 μg/mL) against C. krusei. Additionally, the chromatographic fractionation of the n-butanol fraction from branches afforded four guanidine alkaloids; N-1,N-2,N-3-triisopentenylguanidine (1), described for the first time in the Fabaceae family, and nitensidines A-C (2-4), which showed moderate activity towards C. krusei (MIC = 62.5 μg/mL) and C. parapsilosis (MIC = 31.2 μg/mL).

【 授权许可】

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