Antimicrobial activity of Pterogyne nitens Tul., Fabaceae, against opportunistic fungi

Revista Brasileira de Farmacognosia

Barreiro, Eliezer Jesus¹  Universidade Estadual Paulista Júlio de Mesquita Filho¹  Scorzoni, Liliana¹  Bolzani, Vanderlan da Silva¹  Fusco-Almeida, Ana Marisa¹  Giannini, Maria José Soares Mendes¹  Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil¹  Pivatto, Marcos¹  Benaducci, Tatiane¹  Regasini, Luis Octávio¹  Siva, Dulce Helena Siqueira¹  Universidade Estadual Paulista Júlio de Mesquita Filho, Araraquara, Brazil¹ 

关键词: Pterogyne nitens;    guanidine alkaloids;    antifungal;    opportunistic fungi;    Candida spp.;    Cryptococcus neoformans.;   

DOI  :  10.1590/S0102-695X2010005000017

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

As part of our ongoing research on antifungal agents from Brazilian flora, eight extracts and twelve fractions from Pterogyne nitens Tul., Fabaceae, were screened for antimicrobial activity against four opportunistic fungi species (Candida albicans, Candida krusei, Candida parapsilosis and Cryptococcus neoformans) using a broth microdilution method. The present investigation reveals that P. nitens extracts and fractions were more effective against C. krusei and C. parapsilosis than against C. neoformans. The growth of C. albicans was moderately affected by all tested extracts and fractions. The strongest effects were observed for n-butanol fractions from branches (MIC = 15.6 μg/mL) and roots (MIC = 31.2 μg/mL) against C. krusei. Additionally, the chromatographic fractionation of the n-butanol fraction from branches afforded four guanidine alkaloids; N-1,N-2,N-3-triisopentenylguanidine (1), described for the first time in the Fabaceae family, and nitensidines A-C (2-4), which showed moderate activity towards C. krusei (MIC = 62.5 μg/mL) and C. parapsilosis (MIC = 31.2 μg/mL).

【 授权许可】

Unknown