Behavioral and enzymatic bioassays with Serjania erecta Radlk., Sapindaceae, correlated with cognitive dysfunctions

Revista Brasileira de Farmacognosia

Luciana S. C. Broggini²  Renata S. Fernandes²  Thiago Nogueira²  Fernanda R. Suzano²  Ariadiny L. Caetano¹  Hudson S. Buck¹  Lucelio B. Couto²  Suzelei C. França²  Paulo S Pereira² 

[1] ,Universidade de Ribeirão Preto Unidade de Biotecnologia Ribeirão Preto SP ,Brazil

关键词: Serjania erecta;    antioxidant;    anticholinesterasic;    adaptogen;    Alzheimer;    Serjania erecta;    antioxidante;    anticolinesterase;    adaptógena;    Alzheimer;   

DOI  :  10.1590/S0102-695X2010000400010

来源: SciELO

【 摘 要 】

The purpose of this study was to investigate the crude extract of Serjania erecta Radlk., Sapindaceae, and its bioactive agents as preventive or inhibitor of memory loss in rodents, as well as other factors correlated with Alzheimer's syndrome: antioxidant and anticholinesterase activity, mainly as plant adaptogen - low toxicity and regulation action. The blocking cholinergic reversion activity (scopolamine) in the test of the passive avoidance was detected by measuring latency in young and adult animals. It presented low toxicity, with protective effect as shown by biochemical analysis (hypoglycemic/hypotriglyceridemic). Elevated levels (above 83%) of antioxidant activity were detected. AchE and BuChE inhibition were also detected in the chromatographic fractions, which were active both orally and directly on CNS (ICV).

【 授权许可】

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