Hypoglycemic and hypolipidemic effect of leaves from Syzygium cumini (L.) Skeels, Myrtaceae. in diabetic rats

Revista Brasileira de Farmacognosia

Tatiana Schoenfelder²  Carolini Z. Warmlin¹  Michele S. Manfredini¹  Larissa L. Pavei¹  Juana V. Réus¹  Taciane C. Tristão²  Marcelo S. Fernandes²  Luciane Costa-campos¹ 

[1] ,Universidade do Extremo Sul Catarinense Departamento de Farmácia Criciúma SC ,Brazil

关键词: Syzygium cumini;    Myrtaceae;    diabetes;    hypoglycemic;    hypolipidemic;    medicinal plants;    Syzygium cumini;    Myrtaceae;    diabete;    hipoglicêmico;    hipolipidêmico;    plantas medicinais;   

DOI  :  10.1590/S0102-695X2010000200014

来源: SciELO

【 摘 要 】

Ethanolic crude extract (ECE) of leaves from Syzygium cumini (L.) Skeels, Myrtaceae was screened for its hypoglycemic and hypolipidemic activity (125, 250 and 500 mg/kg v.o.). Rats were divided into three groups for the evaluation of the hypoglycemic effect: normal rats, rats with alloxan-induced diabetes and hyperglycemic normal rats. Hypolipidemia was evaluated in rats with alloxan-induced diabetes. The antihyperglycemic activity was compared to treatment with glibenclamide, an oral hypoglycemic agent. The acute treatment with S. cumini ECE caused a significant decrease in the blood glucose in hyperglycemic normal rats (250 mg/kg), and in glucose (125 and 250 mg/kg), triglyceride (125 and 500 mg/kg) and cholesterol (125 mg/kg) levels of diabetic rats, but no effect was observed in the normal treated rats. Syzygium cumini leaves are a good candidate for alternative and/or complementary medicine in the management of diabetes mellitus, since they showed hypoglycemic activity in addition to a hypolipidemic action in diabetic animals.

【 授权许可】

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