Hypoglycemic and hypolipidemic effect of leaves from Syzygium cumini (L.) Skeels, Myrtaceae. in diabetic rats

Revista Brasileira de Farmacognosia

Tristão, Taciane C.¹  Costa-Campos, Luciane¹  Pavei, Larissa L.¹  Manfredini, Michele S.¹  Schoenfelder, Tatiana¹  Universidade do Extremo Sul Catarinense, Criciúma, Brazil¹  Fernandes, Marcelo S.¹  Réus, Juana V.¹  Warmlin, Carolini Z.¹ 

关键词: Syzygium cumini;    Myrtaceae;    diabetes;    hypoglycemic;    hypolipidemic;    medicinal plants.;   

DOI  :  10.1590/S0102-695X2010000200014

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Ethanolic crude extract (ECE) of leaves from Syzygium cumini (L.) Skeels, Myrtaceae was screened for its hypoglycemic and hypolipidemic activity (125, 250 and 500 mg/kg v.o.). Rats were divided into three groups for the evaluation of the hypoglycemic effect: normal rats, rats with alloxan-induced diabetes and hyperglycemic normal rats. Hypolipidemia was evaluated in rats with alloxan-induced diabetes. The antihyperglycemic activity was compared to treatment with glibenclamide, an oral hypoglycemic agent. The acute treatment with S. cumini ECE caused a significant decrease in the blood glucose in hyperglycemic normal rats (250 mg/kg), and in glucose (125 and 250 mg/kg), triglyceride (125 and 500 mg/kg) and cholesterol (125 mg/kg) levels of diabetic rats, but no effect was observed in the normal treated rats. Syzygium cumini leaves are a good candidate for alternative and/or complementary medicine in the management of diabetes mellitus, since they showed hypoglycemic activity in addition to a hypolipidemic action in diabetic animals.

【 授权许可】

Unknown