Anti-inflammatory activity of Heterotheca subaxillaris var. latifolia (Buckley) Gandhi & R.D. Thomas, Asteraceae

Revista Brasileira de Farmacognosia

Susana Gorzalczany²  Maria A. Rosella¹  Etile D. Spegazzini¹  Cristina Acevedo²  Silvia L. Debenedetti¹ 

[1] ,Universidad de Buenos Aires Facultad de Farmacia y Bioquímica Buenos Aires,Argentina

关键词: Heterotheca subaxillaris var;    latifolia;    Asteraceae;    anti-inflammatory activity;    flavonoids;    Heterotheca subaxillaris var;    latifolia;    Asteraceae;    atividade antiinflamatória;    flavonoides;   

DOI  :  10.1590/S0102-695X2009000600014

来源: SciELO

【 摘 要 】

The anti-inflammatory activity of the petroleum ether, dichloromethane and methanol extracts from Heterotheca subaxillaris var. latifolia were assayed using 12-O-tetradecanoyl phorbol acetate (TPA) induced ear edema test in mice and carrageenan-induced paw edema test in rats. The dichloromethane extract showed a significant anti-inflammatory activity (91% of inhibition) in TPA-induced ear edema test (topical administration at 1 mg/ear). No effects were seen on carragenan-induced edema. Bio-guided fractionation deal to the isolation of the major flavonoids santin, pectolinaringenin, 3,6-dimethoxy-5,7,4'-trihydroxyflavone and hispidulin present in the active fractions.

【 授权许可】

CC BY-NC-ND   
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