Anti-inflammatory activity of Heterotheca subaxillaris var. latifolia (Buckley) Gandhi & R.D. Thomas, Asteraceae

Revista Brasileira de Farmacognosia

Universidad de Belgrano, Buenos Aires, Argentina¹  Debenedetti, Silvia L.¹  Gorzalczany, Susana¹  Rosella, Maria A.¹  Universidad de Buenos Aires, Buenos Aires, Argentina¹  Universidad Nacional de La Plata, La Plata, Argentina¹  Acevedo, Cristina¹  Spegazzini, Etile D.¹ 

关键词: Heterotheca subaxillaris var. latifolia;    Asteraceae;    anti-inflammatory activity;    flavonoids.;   

DOI  :  10.1590/S0102-695X2009000600014

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The anti-inflammatory activity of the petroleum ether, dichloromethane and methanol extracts from Heterotheca subaxillaris var. latifolia were assayed using 12-O-tetradecanoyl phorbol acetate (TPA) induced ear edema test in mice and carrageenan-induced paw edema test in rats. The dichloromethane extract showed a significant anti-inflammatory activity (91% of inhibition) in TPA-induced ear edema test (topical administration at 1 mg/ear). No effects were seen on carragenan-induced edema. Bio-guided fractionation deal to the isolation of the major flavonoids santin, pectolinaringenin, 3,6-dimethoxy-5,7,4'-trihydroxyflavone and hispidulin present in the active fractions.

【 授权许可】

Unknown