Xymarginatin: a new acetogenin inhibitor of mitochondrial electron transport from Xylopia emarginata Mart., Annonaceae

Revista Brasileira de Farmacognosia

Trina Colman-saizarbitoria²  Linda Montilla¹  Maria Rodriguez¹  Aníbal Castillo¹  Masahisa Hasegawa¹ 

[1] ,Universidad Central de Venezuela Facultad de Farmacia Laboratorio de Modelado Molecular y Laboratorio de Bioensayos y Productos NaturalesCaracas,Venezuela

关键词: Xylopia emarginata;    Annocaceae;    acetogenin;    electron transport;    Xylopia emarginata;    Annonaceae;    acetogenina;    transporte eletrônico;   

DOI  :  10.1590/S0102-695X2009000600013

来源: SciELO

【 摘 要 】

A new Annonaceous acetogenin, xymarginatin (1), was isolated from the twigs of Xyliopia emarginata Mart. (Annonaceae) by bioactivity-directed fractionation using lethality to brine shrimp. The compound 1 represents a linear C-35 Annonaceous acetogenin, lacking either tetrahydrofuran (THF) or epoxide rings, bearing a keto group at C-10, and possessing two cis-double bonds separated by two methylenes units. The structure of 1 was elucidated by ¹H and 13C-NMR, COSY, HMBC, HMQC and HRMS. The ability to inhibit the mitochondrial respiratory chain of Xymarginatin (1) was tested in a rat liver mitochondrial oxygen uptake assay, with IC50 value of 1720 nM; Rotenone as a positive control gave IC50 34.8 nM. The toxicity of compound 1 against Artemia salina Leach gave LC50 of 127 μg/mL.

【 授权许可】

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