Revista Brasileira de Farmacognosia | |
Xymarginatin: a new acetogenin inhibitor of mitochondrial electron transport from Xylopia emarginata Mart., Annonaceae | |
Colman-Saizarbitoria, Trina1  Rodriguez, Maria1  Universidad Central de Venezuela, Caracas, Venezuela1  Universidad Central deVenezuela, Caracas, Venezuela1  Castillo, Aníbal1  Hasegawa, Masahisa1  Montilla, Linda1  | |
关键词: Xylopia emarginata; Annocaceae; acetogenin; electron transport.; | |
DOI : 10.1590/S0102-695X2009000600013 | |
来源: Sociedade Brasileira de Farmacognosia | |
【 摘 要 】
A new Annonaceous acetogenin, xymarginatin (1), was isolated from the twigs of Xyliopia emarginata Mart. (Annonaceae) by bioactivity-directed fractionation using lethality to brine shrimp. The compound 1 represents a linear C-35 Annonaceous acetogenin, lacking either tetrahydrofuran (THF) or epoxide rings, bearing a keto group at C-10, and possessing two cis-double bonds separated by two methylenes units. The structure of 1 was elucidated by 1H and 13C-NMR, COSY, HMBC, HMQC and HRMS. The ability to inhibit the mitochondrial respiratory chain of Xymarginatin (1) was tested in a rat liver mitochondrial oxygen uptake assay, with IC50 value of 1720 nM; Rotenone as a positive control gave IC50 34.8 nM. The toxicity of compound 1 against Artemia salina Leach gave LC50 of 127 μg/mL.
【 授权许可】
Unknown
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