Immunostimulatory effects of the phenolic compounds from lichens on nitric oxide and hydrogen peroxide production

Revista Brasileira de Farmacognosia

Iracilda Z. Carlos²  Camila B. A. Carli²  Danielle C. G. Maia²  Fernanda P. Benzatti²  Flavia C. M. Lopes²  Fernanda M. Roese¹  Márcio Watanabe¹  Ana C. Micheletti¹  Lourdes C. Dos Santos¹  Wagner Vilegas¹  Neli K. Honda¹ 

[1] ,São Paulo State University Faculdade de Ciências Farmacêuticas de Araraquara Departament of Clinical Analysis,Brazil

关键词: lichens;    hydrogen peroxide;    nitric oxide;    macrophages;    phenolic compounds;    líquens;    peróxido de hidrogênio;    óxido nítrico;    macrófagos;    compostos fenólicos;   

DOI  :  10.1590/S0102-695X2009000600009

来源: SciELO

【 摘 要 】

The effects of isolated compounds from Brazilian lichens and their derivatives on H2O2 and NO production were studied using murine macrophages as a part of an attempt to understand their possible immunomodulatory properties. The compound cytotoxicity was studied using MTT assay. Macrophage stimulation was evaluated by the determination of NO (Griess assay) and H2O2 (horseradish peroxidase/phenol red) in supernatants of peritoneal macrophage cultures of Swiss mice. This research demonstrated stimulatory activities of some phenolic compounds isolated from lichens and their derivatives on H2O2 and NO production. Structure-activity relationships suggest several synthetic directions for further improvement of immunological activity.

【 授权许可】

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